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From the available mechanistic evidence we inferred that the CYP2C19 metaboliser phenotype of clopidogrel is determined by additive or dominant genetic models of inheritance and that these models also apply to the associations of CYP2C19 with clinical events. We chose dominant genetic models to quantify the effect size in each study by comparing the genotype contrasts of carriers with one or two variant alleles with non carriers of the variant alleles because dominant or additive models have a similar statistical power,32 genotype contrasts are more directly relevant at the individual and the clinical level compared with allele contrasts obtained from additive models, and allele contrasts could not be extracted from all studies.